Please enable Javascript support in your browser to use this application. Otto J. Plescia, ... Anne M. Plescia, in Regulatory Mechanisms in Lymphocyte Activation, 1977.

Possibly significant is the fact that the MCDV-12 line grows more rapidly than the MC-16 line and kills its host in about one-half to one-third the time. Although murine DCs recently were shown to produce low levels of IL-4 in response to Rauscher leukemia virus (Kelleher et al., 1999), human DCs are not known to produce this cytokine. However, during primary allergic sensitisation, the source of IL-4 is unknown although one candidate cell type is the NK T cell (Porcelli and Modlin, 1999). Another strain of mice (BALB/c), inoculated with the MCDV-12 ascites tumor line (induced in BALB/c by Rauscher leukemia virus) was also tested for antibody response to SRBC. ). ; The stoichiometry of p10 binding to Rauscher virus RNA was analyzed using both 125I-labeled p10 and 3H-labeled RNA . The half-life of RNase H+ RTase at 37°C is ∼15 min, which means that 10–20 times more MoLV RTase than AMV RTase is required to synthesize an equivalent amount of cDNA products (7).

In order to establish the role, if any, of the syngeneic tumor in the suppression of the antibody response of tumor-bearing mice to SRBC, spleen cells of normal C57BL/6J mice were cultured in vitro with syngeneic MC-16 tumor cells, ranging in number from 103 to 105 per 107 spleen cells, and SRBC were added directly to these cultures to induce antibody formation. oligo(dG) and AMV 70S RNA (17).

In the above experiment viable tumor cells, prepared from freshly excised tumors of passage mice, were used, and they were added to cultures of spleen cells essentially at the same time as SRBC.

IL-6, produced by human DCs in response to inflammatory stimuli (Verhasselt et al., 1997), may induce TH2 differentiation since IL-6 has been shown to initiate IL-4 production by naïve T cells (Rincon et al., 1997). Instructions on how to enable JavaScript on different browsers can be found here: Spleen focus formation induced by MHSV and Ha-MuSV was not restricted by the Fv-2 resistance locus in congenic DDD and C57BL/6 mice, unlike leukemogenesis induced by, These results indicate that most, if not all, of the oligosaccharides at the surface of, Specific sequences of the env gene determine the host range of two XC-negative viruses of the,

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Much of the current information on this page has been automatically compiled from Pubmed. Holgate, in Dendritic Cells (Second Edition), 2001.

All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Clearly there was evidence of immunodepression in both strains, and because the tumors and SRBC are antigenically unrelated it may be concluded that the immunodepression was generalized rather than specific. Fig. The results of these experiments show that the extent of immunosuppression by the tumor cells increases with time of interaction, and decreases with their loss of viability (5). Tell a friend about us , add a link to this page, or visit the webmaster's page for free fun content .

In this system the tumor cells proved very active in suppressing antibody response (Figure 1). They recognise novel lipid antigens presented by CD1d, and presumably critically depend on DCs for antigen presentation. By continuing you agree to the use of cookies.

(Reprinted from P.N.A.S., Centrifugal Separations in Molecular and Cell Biology. These tumor-bearing mice, in contrast to the C57BL/6J mice bearing the MC-16 tumor, were significantly depressed immunologically by the fourth day (5). The most important cellular source of IL-4 is a subject of debate in the field of allergy research. Both inflammatory and constitutive chemokines of the CC and CXC families are produced by DCs and are able to assist in establishing contact between DCs and T cells.

in a single dose, and the antibody response occurred in vivo.

Other T cells that recognise lipid and glycolipid components of, for example, mycobacteria, in a CD1-a, -b or -c-restricted manner exist.

Its antiretroviral spectrum covers HIV-1 and HIV-2, simian immunodeficiency virus (SIV), Enzymology Primer for Recombinant DNA Technology, Epidemiology of Multiple Myeloma and Related Plasma Cell Disorders: An Analytic Review, IMMUNOSUBVERSIVE ACTIVITY OF TUMOR CELLS AS AN ESCAPE MECHANISM, Regulatory Mechanisms in Lymphocyte Activation. What does rauscher virus mean?

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